{"id":1021,"date":"2022-06-03T18:02:16","date_gmt":"2022-06-03T16:02:16","guid":{"rendered":"http:\/\/www.posi-lab.fr\/?p=1021"},"modified":"2025-02-05T22:56:50","modified_gmt":"2025-02-05T21:56:50","slug":"lung-adapted-staphylococcus-aureus-trigger-a-proinflammatory-response","status":"publish","type":"post","link":"https:\/\/www.host-pathogen-biology.fr\/index.php\/2022\/06\/03\/lung-adapted-staphylococcus-aureus-trigger-a-proinflammatory-response\/","title":{"rendered":"Lung-Adapted Staphylococcus aureus Trigger a Proinflammatory Response"},"content":{"rendered":"\n<p>07\/05\/2022 . <br>Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response<br><a href=\"https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiac191\/6582315?login=true\" target=\"_blank\" rel=\"noreferrer noopener\">Elodie Ramond <em>et al <\/em>The Journal of Infectious Diseases 2022<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"396\" height=\"222\" src=\"http:\/\/www.posi-lab.fr\/wp-content\/uploads\/2022\/06\/image-2.png\" alt=\"\" class=\"wp-image-1022\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2022\/06\/image-2.png 396w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2022\/06\/image-2-300x168.png 300w\" sizes=\"auto, (max-width: 396px) 100vw, 396px\" \/><\/figure>\n\n\n\n<p><strong>Background<\/strong><br><em>Staphylococcus aureus<\/em>&nbsp;dominates the lung microbiota of children with cystic fibrosis (CF) and persistent clones are able to establish chronic infection for years, having a direct deleterious impact on lung function. However, in this context, the exact contribution of&nbsp;<em>S. aureus<\/em>&nbsp;to the decline in respiratory function in children with CF is not elucidated.<\/p>\n\n\n\n<p><strong>Methods<\/strong><br>To investigate the contribution of persistent&nbsp;<em>S. aureus<\/em>&nbsp;clones in CF disease, we undertook the analysis of sequential isogenic isolates recovered from 15 young CF patients.<\/p>\n\n\n\n<p><strong>Results<\/strong><br>Using an air-liquid infection model, we observed a strong correlation between&nbsp;<em>S. aureus<\/em>&nbsp;adaption in the lung (late isolates), low toxicity, and proinflammatory cytokine secretion. Conversely, early isolates appeared to be highly cytotoxic but did not promote cytokine secretion. We found that cytokine secretion was dependent on staphylococcal protein A (Spa), which was selectively expressed in late compared to early isolates as a consequence of dysfunctional agr quorum-sensing system. Finally, we demonstrated the involvement of TNF-\u03b1 receptor 1 signaling in the inflammatory response of airway epithelial cells to these lung-adapted&nbsp;<em>S. aureus<\/em>&nbsp;isolates.<\/p>\n\n\n\n<p><strong>Conclusions<\/strong><br>Our results suggest an unexpected direct role of bacterial lung adaptation in the progression of chronic lung disease by promoting a proinflammatory response through acquired agr dysfunction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>07\/05\/2022 . Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory ResponseElodie Ramond et al The Journal of Infectious Diseases 2022 BackgroundStaphylococcus aureus&nbsp;dominates the lung microbiota of children &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1080,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,27],"tags":[],"class_list":["post-1021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aaward-grant","category-tsa"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lung-Adapted Staphylococcus aureus Trigger a Proinflammatory Response - PoSI-Lab<\/title>\n<meta name=\"description\" content=\"Lung-Adapted Staphylococcus aureus Trigger a Proinflammatory Response, PoSI-Lab, INEM, Institut Necker Enfants 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