{"id":1076,"date":"2023-03-27T11:40:25","date_gmt":"2023-03-27T09:40:25","guid":{"rendered":"http:\/\/www.posi-lab.fr\/?p=1076"},"modified":"2025-02-05T22:56:12","modified_gmt":"2025-02-05T21:56:12","slug":"engineered-human-microvasculature-to-study-human-infectious-diseases","status":"publish","type":"post","link":"https:\/\/www.host-pathogen-biology.fr\/index.php\/2023\/03\/27\/engineered-human-microvasculature-to-study-human-infectious-diseases\/","title":{"rendered":"Engineered human microvasculature to study human infectious diseases"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">27\/03\/2023 . <br>Implantation of engineered human microvasculature to study human infectious diseases in mouse models.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36942053\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sophia Sch\u00f6nherr-Hellec <em>et al <\/em>iScience 2023<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.posi-lab.fr\/wp-content\/uploads\/2023\/03\/iScience_2023.jpg\" alt=\"\" class=\"wp-image-1077\" width=\"449\" height=\"448\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2023\/03\/iScience_2023.jpg 524w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2023\/03\/iScience_2023-300x300.jpg 300w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2023\/03\/iScience_2023-150x150.jpg 150w\" sizes=\"auto, (max-width: 449px) 100vw, 449px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows investigation of pathogen interactions with the endothelium, including\u00a0<em>in vivo<\/em>\u00a0functional studies. Using\u00a0<em>Neisseria meningitidis<\/em>\u00a0as a paradigm of human-restricted infection, we demonstrated the strength and opportunities associated with the use of this approach.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>27\/03\/2023 . Implantation of engineered human microvasculature to study human infectious diseases in mouse models.Sophia Sch\u00f6nherr-Hellec et al iScience 2023 Animal models for studying human pathogens are crucially lacking. We &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1078,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,26],"tags":[],"class_list":["post-1076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aaward-grant","category-tnm"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Engineered human microvasculature to study human infectious diseases - PoSI-LabEngineered human microvasculature to study human infectious diseases<\/title>\n<meta name=\"description\" content=\"Engineered human microvasculature to study human infectious diseases, PoSI-Lab, INEM, Institut Necker Enfants Malades, Mathieu Coureuil, Inserm\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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