{"id":1192,"date":"2025-02-03T23:00:19","date_gmt":"2025-02-03T22:00:19","guid":{"rendered":"https:\/\/www.host-pathogen-biology.fr\/?p=1192"},"modified":"2025-02-05T22:55:23","modified_gmt":"2025-02-05T21:55:23","slug":"dual-proteomics-of-infected-macrophages-in-the-francisella-intracellular-life-cycle","status":"publish","type":"post","link":"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/02\/03\/dual-proteomics-of-infected-macrophages-in-the-francisella-intracellular-life-cycle\/","title":{"rendered":"Dual proteomics of infected macrophages in the\u00a0Francisella\u00a0intracellular life cycle"},"content":{"rendered":"\n<p>02\/04\/2024. <br>Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy<br><a href=\"https:\/\/www-nature-com.proxy.insermbiblio.inist.fr\/articles\/s41598-024-58261-x\">H\u00e9lo\u00efse Rytter <em>et al<\/em> Scientific Reports 2024<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Abs1\">Abstract<\/h2>\n\n\n\n<p>Bacterial pathogens adapt and replicate within host cells, while host cells develop mechanisms to eliminate them. Using a dual proteomic approach, we characterized the intra-macrophage proteome of the facultative intracellular pathogen,&nbsp;<em>Francisella novicida<\/em>. More than 900&nbsp;<em>Francisella<\/em>&nbsp;proteins were identified in infected macrophages after a 10-h infection. Biotin biosynthesis-related proteins were upregulated, emphasizing the role of biotin-associated genes in Francisella replication. Conversely, proteins encoded by the&nbsp;<em>Francisella<\/em>&nbsp;pathogenicity island (FPI) were downregulated, supporting the importance of the&nbsp;<em>F. tularensis<\/em>&nbsp;Type VI Secretion System for vacuole escape, not cytosolic replication. In the host cell, over 300 proteins showed differential expression among the 6200 identified during infection. The most upregulated host protein was cis-aconitate decarboxylase IRG1, known for itaconate production with antimicrobial properties in&nbsp;<em>Francisella<\/em>. Surprisingly, disrupting IRG1 expression did not impact&nbsp;<em>Francisella<\/em>\u2019s intracellular life cycle, suggesting redundancy with other immune proteins or inclusion in larger complexes. Over-representation analysis highlighted cell\u2013cell contact and actin polymerization in macrophage deregulated proteins. Using flow cytometry and live cell imaging, we demonstrated that merocytophagy involves diverse cell-to-cell contacts and actin polymerization-dependent processes. These findings lay the groundwork for further exploration of merocytophagy and its molecular mechanisms in future research.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"685\" height=\"473\" src=\"http:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/02\/41598_2024_58261_Fig1_HTML.webp\" alt=\"\" class=\"wp-image-1193\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/02\/41598_2024_58261_Fig1_HTML.webp 685w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/02\/41598_2024_58261_Fig1_HTML-300x207.webp 300w\" sizes=\"auto, (max-width: 685px) 100vw, 685px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>02\/04\/2024. Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagyH\u00e9lo\u00efse Rytter et al Scientific Reports &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1196,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1192","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aaward-grant"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dual proteomics of infected macrophages in the\u00a0Francisella\u00a0intracellular life cycle - Host Pathogen Biology Team Host Pathogen Integrative Biology<\/title>\n<meta name=\"description\" content=\"Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy, Host Pathogen Integrative Biology, INEM, Institut Necker Enfants Malades, Paris, Inserm, CNRS, Universit\u00e9 de Paris\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/02\/03\/dual-proteomics-of-infected-macrophages-in-the-francisella-intracellular-life-cycle\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dual proteomics of infected macrophages in the\u00a0Francisella\u00a0intracellular life cycle - Host Pathogen Biology Team Host Pathogen Integrative Biology\" \/>\n<meta property=\"og:description\" content=\"Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular 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