{"id":1423,"date":"2025-12-20T11:54:03","date_gmt":"2025-12-20T10:54:03","guid":{"rendered":"https:\/\/www.host-pathogen-biology.fr\/?p=1423"},"modified":"2026-01-27T12:53:40","modified_gmt":"2026-01-27T11:53:40","slug":"the-mda-promotes-bacterial-colonisation","status":"publish","type":"post","link":"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/20\/the-mda-promotes-bacterial-colonisation\/","title":{"rendered":"The MDA promotes bacterial colonisation by selecting hyperadhesive pili variants"},"content":{"rendered":"\n<p>20\/12\/2025<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-2b49f68dd0b1f1ce4e4f0778822466d0\"><em>Neisseria meningitidis<\/em> filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-025-67441-w\" target=\"_blank\" rel=\"noreferrer noopener\">Cl\u00e9mence Mouville,\u00a0Antoine Brizard,\u00a0Morgane Wuckelt,\u00a0M\u00e9lanie Montabord,\u00a0Herv\u00e9 L\u00e9cuyer,\u00a0Julie Meyer,\u00a0Anne Jamet,\u00a0B\u00e9atrice Durel,\u00a0Charlotte Izabelle,\u00a0Xavier Nassif,\u00a0Mathieu Coureuil,\u00a0Emmanuelle Bille<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Abstract<\/strong><\/h2>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-e4b11c6e31edf82c9814c2078674dc30\">Filamentous phages are non-lytic phages mutually beneficial to their bacterial hosts. In&nbsp;<em>Neisseria meningitidis<\/em>, the filamentous phage MDA is associated with invasive diseases thanks to its key role in the formation of biofilm during epithelium colonisation. The infection model for filamentous phages has been defined for phages Ff and CTX. These phages bind to the tips of bacterial pili before being translocated into the periplasm of their hosts. The aim of this study is to investigate the relationship between filamentous phage infection and type IV pili, using the bacterium&nbsp;<em>Neisseria meningitidis<\/em>&nbsp;and the bacteriophage MDA as model organisms. We show that MDA\u03a6 rather binds to type IV pili along their entire length with preferential binding to positively charged variants of the major fibre-forming pilin, demonstrating a role for antigenic variation in phage infection. Strikingly, bacteria expressing the more positively charged pilin are also the most adhesive, suggesting that MDA\u03a6 primarily target the most adhesive bacteria. Finally, we show that adhesion to human cells is sufficient to amplify the phage-positive meningococcal population. Overall, this study reveals how a filamentous phage can target hyperadhesive bacterial variants and promote their selection, thereby establishing a link between phage infection and bacterial colonisation.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"320\" height=\"320\" src=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2026\/01\/image.png\" alt=\"\" class=\"wp-image-1425\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2026\/01\/image.png 320w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2026\/01\/image-300x300.png 300w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2026\/01\/image-150x150.png 150w\" sizes=\"auto, (max-width: 320px) 100vw, 320px\" \/><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>20\/12\/2025 Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants Cl\u00e9mence Mouville,\u00a0Antoine Brizard,\u00a0Morgane Wuckelt,\u00a0M\u00e9lanie Montabord,\u00a0Herv\u00e9 L\u00e9cuyer,\u00a0Julie Meyer,\u00a0Anne Jamet,\u00a0B\u00e9atrice Durel,\u00a0Charlotte Izabelle,\u00a0Xavier Nassif,\u00a0Mathieu Coureuil,\u00a0Emmanuelle Bille Abstract Filamentous phages are &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,26],"tags":[],"class_list":["post-1423","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aaward-grant","category-tnm"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The MDA promotes bacterial colonisation by selecting hyperadhesive pili variants - Host Pathogen Biology Team Host Pathogen Integrative Biology<\/title>\n<meta name=\"description\" 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