{"id":320,"date":"2020-04-09T17:19:25","date_gmt":"2020-04-09T15:19:25","guid":{"rendered":"http:\/\/tnroetk.cluster028.hosting.ovh.net\/?p=320"},"modified":"2025-02-03T22:41:50","modified_gmt":"2025-02-03T21:41:50","slug":"emmanuelle-bille","status":"publish","type":"post","link":"https:\/\/www.host-pathogen-biology.fr\/index.php\/2020\/04\/09\/emmanuelle-bille\/","title":{"rendered":"Emmanuelle Bille"},"content":{"rendered":"\n<figure class=\"wp-block-gallery has-nested-images columns-0 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"652\" height=\"303\" data-id=\"595\" src=\"http:\/\/www.posi-lab.fr\/wp-content\/uploads\/2020\/04\/EB_02.jpg\" alt=\"\" class=\"wp-image-595\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2020\/04\/EB_02.jpg 652w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2020\/04\/EB_02-300x139.jpg 300w\" sizes=\"auto, (max-width: 652px) 100vw, 652px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"588\" height=\"299\" data-id=\"597\" src=\"http:\/\/www.posi-lab.fr\/wp-content\/uploads\/2020\/05\/EB_01-1.jpg\" alt=\"\" class=\"wp-image-597\" srcset=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2020\/05\/EB_01-1.jpg 588w, https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2020\/05\/EB_01-1-300x153.jpg 300w\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" \/><\/figure>\n<\/figure>\n\n\n\n<p class=\"has-very-dark-gray-color has-text-color wp-block-paragraph\">Emmanuelle Bille is leader of the thematic Filamentous Phage in the Neisseria team. <br>EB is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of \u00ab Pathogenesis of Systemic Infections \u00bb (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children\u2019s Hospital.<br>Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on&nbsp;<em>Neisseriameningitidis<\/em>&nbsp;virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDA\u03a6 for Meningococcal Disease Associated, associated with invasive diseases caused by&nbsp;<em>N. meningitidis<\/em>. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDA\u03a6 seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"74\" src=\"http:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2023\/03\/LOGO_Phages_fr.png\" alt=\"\" class=\"wp-image-1065\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">We are member of the Bacteriophage Network France : <a href=\"https:\/\/site.phages.fr\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/site.phages.fr\/<\/a> <\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-very-dark-gray-color has-text-color has-medium-font-size wp-block-paragraph\"><strong>Last News of the Lab<\/strong><br><div class=\"pt-cv-wrapper\"><div class=\"pt-cv-view pt-cv-grid pt-cv-colsys\" id=\"pt-cv-view-f1300adszx\"><div data-id=\"pt-cv-page-1\" class=\"pt-cv-page\" data-cvc=\"1\"><div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\" ><div class='pt-cv-ifield'><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2026\/03\/10\/vulgarisation-scientifique-microcros\/\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2026\/03\/MicroCrocs-150x150.jpg\" class=\"pt-cv-thumbnail pull-left\" alt=\"\" \/><\/a>\n<h4 class=\"pt-cv-title\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2026\/03\/10\/vulgarisation-scientifique-microcros\/\" class=\"_self\" target=\"_self\" >Vulgarisation scientifique @MicroCros<\/a><\/h4>\n<div class=\"pt-cv-content\">10\/03\/2026 Les bact\u00e9ries manipulent nos cellules gr\u00e2ce \u00e0 la physique Audrey Laurent Granger Les bact\u00e9ries sont partout, y compris \u00e0 ...<br \/><div class=\"pt-cv-rmwrap\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2026\/03\/10\/vulgarisation-scientifique-microcros\/\" class=\"_self pt-cv-readmore btn btn-success\" target=\"_self\">Lire La Suite\u2026<\/a><\/div><\/div><\/div><\/div>\n<div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\" ><div class='pt-cv-ifield'><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/20\/the-mda-promotes-bacterial-colonisation\/\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/12\/Nat-commun-150x150.jpg\" class=\"pt-cv-thumbnail pull-left\" alt=\"\" \/><\/a>\n<h4 class=\"pt-cv-title\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/20\/the-mda-promotes-bacterial-colonisation\/\" class=\"_self\" target=\"_self\" >The MDA promotes bacterial colonisation by selecting hyperadhesive pili variants<\/a><\/h4>\n<div class=\"pt-cv-content\">20\/12\/2025 Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants Cl\u00e9mence Mouville,\u00a0Antoine Brizard,\u00a0Morgane Wuckelt,\u00a0M\u00e9lanie Montabord,\u00a0Herv\u00e9 L\u00e9cuyer,\u00a0Julie Meyer,\u00a0Anne ...<br \/><div class=\"pt-cv-rmwrap\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/20\/the-mda-promotes-bacterial-colonisation\/\" class=\"_self pt-cv-readmore btn btn-success\" target=\"_self\">Lire La Suite\u2026<\/a><\/div><\/div><\/div><\/div>\n<div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\" ><div class='pt-cv-ifield'><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/05\/meningococci-reshape-host-membranes-to-recruit-their-own-signaling-receptors\/\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/12\/Nat-commun-150x150.jpg\" class=\"pt-cv-thumbnail pull-left\" alt=\"\" \/><\/a>\n<h4 class=\"pt-cv-title\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/05\/meningococci-reshape-host-membranes-to-recruit-their-own-signaling-receptors\/\" class=\"_self\" target=\"_self\" >Meningococci reshape host membranes to recruit their own signaling receptors<\/a><\/h4>\n<div class=\"pt-cv-content\">05\/12\/2025. Meningococci drive host membrane tubulation to recruit their signaling receptors Audrey Laurent-Granger, K\u00e9vin Sollier, Bruno Saubamea, Virginie Mignon, Nicolas ...<br \/><div class=\"pt-cv-rmwrap\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/12\/05\/meningococci-reshape-host-membranes-to-recruit-their-own-signaling-receptors\/\" class=\"_self pt-cv-readmore btn btn-success\" target=\"_self\">Lire La Suite\u2026<\/a><\/div><\/div><\/div><\/div>\n<div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\" ><div class='pt-cv-ifield'><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/10\/01\/newcomers-in-the-lab\/\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.host-pathogen-biology.fr\/wp-content\/uploads\/2025\/02\/HPIB-logo-news-150x150.png\" class=\"pt-cv-thumbnail pull-left\" alt=\"\" \/><\/a>\n<h4 class=\"pt-cv-title\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/10\/01\/newcomers-in-the-lab\/\" class=\"_self\" target=\"_self\" >Newcomers in the Lab<\/a><\/h4>\n<div class=\"pt-cv-content\">01\/10\/2025. It's time to welcome Five new lab members: Anne-Aur\u00e9lie Lopes, MD, PhD, HDR. Anne Aur\u00e9lie join the lab and ...<br \/><div class=\"pt-cv-rmwrap\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/10\/01\/newcomers-in-the-lab\/\" class=\"_self pt-cv-readmore btn btn-success\" target=\"_self\">Lire La Suite\u2026<\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p class=\"has-very-dark-gray-color has-text-color has-medium-font-size wp-block-paragraph\"><strong>Team Members<br><\/strong><ul class=\"lcp_catlist\" id=\"lcp_instance_0\"><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2020\/04\/09\/mathieu-coureuil\/\">Mathieu Coureuil<\/a><\/li><li class=\"current\"><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2020\/04\/09\/emmanuelle-bille\/\">Emmanuelle Bille<\/a><\/li><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2020\/04\/07\/xavier-nassif\/\">Xavier Nassif<\/a><\/li><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/11\/03\/mariam-wehbi\/\">Mariam Wehbi<\/a><\/li><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2023\/01\/25\/morgane-wuckelt\/\">Morgane Wuckelt<\/a><\/li><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2025\/02\/04\/lison-reboul\/\">Lison Reboul<\/a><\/li><li><a href=\"https:\/\/www.host-pathogen-biology.fr\/index.php\/2023\/01\/26\/julie-brousseau\/\">Julie Brousseau<\/a><\/li><\/ul><\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<p class=\"has-very-dark-gray-color has-text-color has-medium-font-size wp-block-paragraph\"><strong>Last Publications<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><!-- load from cache<br> --><ol><li>de Cacqueray, N, Oualha, M, Foissac, F, Bournaud, LF, Lui, G, Bille, E <i>et al.<\/i>. Piperacillin Population Pharmacokinetics in Plasma and Peritoneal Fluid and Dosing Optimization in Children Undergoing Liver Transplant: An Optimome Study. Clin Pharmacol Ther. 2026; :. doi: <a href='http:\/\/dx.doi.org\/10.1002\/cpt.70346'>10.1002\/cpt.70346<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/42216238'>PMID:42216238<\/a> .<\/li><li>Attaianese, F, Benhard, J, Cohen, JF, Vegas, N, Bille, E, Flamant, A <i>et al.<\/i>. Oral switch therapy for paediatric Staphylococcus aureus bloodstream infections: A retrospective study in a tertiary hospital. Int J Infect Dis. 2026;167 :108551. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.ijid.2026.108551'>10.1016\/j.ijid.2026.108551<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41846044'>PMID:41846044<\/a> .<\/li><li>Mouville, C, Brizard, A, Wuckelt, M, Montabord, M, L\u00e9cuyer, H, Meyer, J <i>et al.<\/i>. Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants. Nat Commun. 2025;17 (1):744. doi: <a href='http:\/\/dx.doi.org\/10.1038\/s41467-025-67441-w'>10.1038\/s41467-025-67441-w<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41422109'>PMID:41422109<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12819557'>PMC12819557<\/a>.<\/li><li>Girlich, D, Emeraud, C, Jacquemin, A, Guet-Revillet, H, Ranc, AG, Reissier, S <i>et al.<\/i>. Sphingobacterium spp. as intrinsic producers of SPI Ambler class B metallo-&#x3b2;-lactamases. J Antimicrob Chemother. 2026;81 (1):. doi: <a href='http:\/\/dx.doi.org\/10.1093\/jac\/dkaf436'>10.1093\/jac\/dkaf436<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41330414'>PMID:41330414<\/a> .<\/li><li>Laurent-Granger, A, Sollier, K, Saubamea, B, Mignon, V, Goudin, N, Wormser, Y <i>et al.<\/i>. Meningococci drive host membrane tubulation to recruit their signaling receptors. Nat Commun. 2025;16 (1):10433. doi: <a href='http:\/\/dx.doi.org\/10.1038\/s41467-025-65436-1'>10.1038\/s41467-025-65436-1<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41290585'>PMID:41290585<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12647851'>PMC12647851<\/a>.<\/li><li>B\u00f6hning, J, Graham, M, Coureuil, M, Tarafder, AK, Meyer, J, Nassif, X <i>et al.<\/i>. Structure of the virulence-associated <i>Neisseria meningitidis<\/i> filamentous bacteriophage MDA&#x3a6;. Proc Natl Acad Sci U S A. 2025;122 (25):e2420157122. doi: <a href='http:\/\/dx.doi.org\/10.1073\/pnas.2420157122'>10.1073\/pnas.2420157122<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40540604'>PMID:40540604<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12207478'>PMC12207478<\/a>.<\/li><li>Bernheim, S, Chikhi, S, Foufa, I, Parize, P, Bille, E, Pontailler, M <i>et al.<\/i>. Postoperative Mediastinitis in Pediatric Cardiac Surgery: Clinical Characteristics, Management and Risk Factors for Mortality. Pediatr Infect Dis J. 2025;44 (11):1025-1029. doi: <a href='http:\/\/dx.doi.org\/10.1097\/INF.0000000000004882'>10.1097\/INF.0000000000004882<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40472255'>PMID:40472255<\/a> .<\/li><li>Chebib, E, Ok, V, Cohen, JF, L\u00e9ger, M, Lecuyer, H, Bille, E <i>et al.<\/i>. Changes in Clinical and Microbiological Characteristics of Acute Mastoiditis in Children: A Comparative Study Between 2001-2008 and 2021-2024. J Pediatr. 2025;285 :114672. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.jpeds.2025.114672'>10.1016\/j.jpeds.2025.114672<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40447134'>PMID:40447134<\/a> .<\/li><li>Bille, E, Schubert-Unkmeir, A, Coureuil, M. Neisseria meningitidis. Trends Microbiol. 2025;33 (3):370-371. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.tim.2025.01.001'>10.1016\/j.tim.2025.01.001<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39863510'>PMID:39863510<\/a> .<\/li><li>Marsaux, A, L\u00e9ger, PL, Rambaud, J, Bille, E, Renolleau, S, Tr\u00e9luyer, JM <i>et al.<\/i>. Beta-Lactam Antibiotic Exposure During Pediatric Extracorporeal Membrane Oxygenation: Retrospective Cohort Analysis of Drug Levels Using Standard Dosing, 2018-2020. Pediatr Crit Care Med. 2024;25 (12):1127-1137. doi: <a href='http:\/\/dx.doi.org\/10.1097\/PCC.0000000000003605'>10.1097\/PCC.0000000000003605<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39630067'>PMID:39630067<\/a> .<\/li><li>Heid-Picard, B, Mougari, F, Pouvaret, A, Lanternier, F, Awad, Z, Bille, E <i>et al.<\/i>. Extrapulmonary Mycobacterium abscessus Infections, France, 2012-2020<sup>1<\/sup>. Emerg Infect Dis. 2024;30 (11):2294-302. doi: <a href='http:\/\/dx.doi.org\/10.3201\/eid3011.240459'>10.3201\/eid3011.240459<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39447147'>PMID:39447147<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11521186'>PMC11521186<\/a>.<\/li><li>Rivaud, C, Oualha, M, Salvador, E, Bille, E, Callot, D, B\u00e9ranger, A <i>et al.<\/i>. Improving cefazolin exposure in critically ill children using a population pharmacokinetic model. Br J Clin Pharmacol. 2025;91 (4):981-988. doi: <a href='http:\/\/dx.doi.org\/10.1111\/bcp.16224'>10.1111\/bcp.16224<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39209527'>PMID:39209527<\/a> .<\/li><li>Wuckelt, M, Laurent, A, Mouville, C, Meyer, J, Jamet, A, Lecuyer, H <i>et al.<\/i>. Expanding the genetic toolbox for <i>Neisseria meningitidis<\/i> with efficient tools for unmarked gene editing, complementation, and labeling. Appl Environ Microbiol. 2024;90 (9):e0088024. doi: <a href='http:\/\/dx.doi.org\/10.1128\/aem.00880-24'>10.1128\/aem.00880-24<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39140741'>PMID:39140741<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11409642'>PMC11409642<\/a>.<\/li><li>Bes-Berlandier, H, Garzaro, M, Rouzaud, C, Bodard, S, Bille, E, Ficheux, M <i>et al.<\/i>. Successful rescue TNF-&#x3b1; blocking for <i>Mycobacterium genavense<\/i> - Related immune reconstitution inflammatory syndrome: A case report. Heliyon. 2024;10 (7):e29341. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.heliyon.2024.e29341'>10.1016\/j.heliyon.2024.e29341<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/38623247'>PMID:38623247<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11016716'>PMC11016716<\/a>.<\/li><li>Faury, H, Stanzelova, A, Ferroni, A, Belhous, K, Morand, P, Toubiana, J <i>et al.<\/i>. Mycobacterium canettii Tuberculosis Lymphadenopathy in a 3-Year-old Child. Pediatr Infect Dis J. 2023;42 (9):e345-e347. doi: <a href='http:\/\/dx.doi.org\/10.1097\/INF.0000000000003983'>10.1097\/INF.0000000000003983<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37235762'>PMID:37235762<\/a> .<\/li><li>Tin\u00e9vez, C, Lehours, P, Ranc, AG, Belaroussi, Y, Velardo, F, Dubois, D <i>et al.<\/i>. Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Campylobacter spp., France. Emerg Infect Dis. 2023;29 (3):484-492. doi: <a href='http:\/\/dx.doi.org\/10.3201\/eid2903.221417'>10.3201\/eid2903.221417<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36823023'>PMID:36823023<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9973684'>PMC9973684<\/a>.<\/li><li>Jousset, AB, Bernabeu, S, Emeraud, C, Bonnin, RA, Lomont, A, Zahar, JR <i>et al.<\/i>. Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales. J Glob Antimicrob Resist. 2023;32 :78-84. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.jgar.2023.01.003'>10.1016\/j.jgar.2023.01.003<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36708769'>PMID:36708769<\/a> .<\/li><li>Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L <i>et al.<\/i>. Correction to: Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):975-976. doi: <a href='http:\/\/dx.doi.org\/10.1007\/s00431-022-04762-8'>10.1007\/s00431-022-04762-8<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36529772'>PMID:36529772<\/a> .<\/li><li>Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L <i>et al.<\/i>. Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):965-973. doi: <a href='http:\/\/dx.doi.org\/10.1007\/s00431-022-04716-0'>10.1007\/s00431-022-04716-0<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36422708'>PMID:36422708<\/a> .<\/li><li>Thy, M, Urien, S, Foissac, F, Bouazza, N, Gana, I, Bille, E <i>et al.<\/i>. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2022;66 (12):e0113522. doi: <a href='http:\/\/dx.doi.org\/10.1128\/aac.01135-22'>10.1128\/aac.01135-22<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36342152'>PMID:36342152<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9764994'>PMC9764994<\/a>.<\/li><li>Thy, M, Urien, S, Bouazza, N, Foissac, F, Gana, I, Bille, E <i>et al.<\/i>. Meropenem Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Clin Pharmacokinet. 2022;61 (11):1609-1621. doi: <a href='http:\/\/dx.doi.org\/10.1007\/s40262-022-01179-2'>10.1007\/s40262-022-01179-2<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36251162'>PMID:36251162<\/a> .<\/li><li>Pizzato, J, Tang, W, Bernabeu, S, Bonnin, RA, Bille, E, Farfour, E <i>et al.<\/i>. Discrimination of <i>Escherichia coli<\/i>, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI-TOF mass spectrometry paired with machine learning. Microbiologyopen. 2022;11 (4):e1313. doi: <a href='http:\/\/dx.doi.org\/10.1002\/mbo3.1313'>10.1002\/mbo3.1313<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36004556'>PMID:36004556<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9405496'>PMC9405496<\/a>.<\/li><li>de Cacqueray, N, Hirt, D, Zheng, Y, Bille, E, Leger, PL, Rambaud, J <i>et al.<\/i>. Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function. Clin Microbiol Infect. 2022;28 (10):1389.e1-1389.e7. doi: <a href='http:\/\/dx.doi.org\/10.1016\/j.cmi.2022.05.007'>10.1016\/j.cmi.2022.05.007<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35605841'>PMID:35605841<\/a> .<\/li><li>Farfour, E, Dortet, L, Guillard, T, Chatelain, N, Poisson, A, Mizrahi, A <i>et al.<\/i>. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France. Pathogens. 2022;11 (3):. doi: <a href='http:\/\/dx.doi.org\/10.3390\/pathogens11030356'>10.3390\/pathogens11030356<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35335681'>PMID:35335681<\/a> PubMed Central <a href='http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8949168'>PMC8949168<\/a>.<\/li><li>de Cacqueray, N, Boujaafar, S, Bille, E, Moulin, F, Gana, I, Benaboud, S <i>et al.<\/i>. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. Ther Drug Monit. 2022;44 (2):319-327. doi: <a href='http:\/\/dx.doi.org\/10.1097\/FTD.0000000000000918'>10.1097\/FTD.0000000000000918<\/a>. PubMed <a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35292609'>PMID:35292609<\/a> .<\/ol><a href='http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=(bille,+emmanuelle[Author])'>Search PubMed<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emmanuelle Bille is leader of the thematic Filamentous Phage in the Neisseria team. EB is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18,41],"tags":[],"class_list":["post-320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neisseria_meningitidis","category-pi"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Emmanuelle Bille - Host Pathogen Biology Team Host Pathogen Integrative Biology<\/title>\n<meta name=\"description\" content=\"Emmanuelle Bille, Host Pathogen Integrative Biology, INEM, Institut Necker Enfants Malades, Paris, Inserm, CNRS, Universit\u00e9 de Paris\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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