01/07/2025.
Anne Jamet in collaboration with Asmaa Tazi (Institut Cochin) were granted by the Microb’EX network
Polymicrobial infections are frequently seen in patients with skin wounds. Despite their prevalence, polymicrobial infections remain underexplored and their clinical management poorly codified. Staphylococcus aureus and Streptococcus pyogenes can co-infect skin lesions with the potential for metabolic cooperation. In particular, our preliminary data suggest that the interaction between both species may impact their transcriptional program, which can exacerbate skin lesions and promote tissue invasion. In this project, we will study how Sa-GAS interactions influence bacterial metabolism, transcriptional programs, in vivo virulence and host immune response. To carry out this project, our team will collaborate with the team of Pr Asmaa Tazi (Institut Cochin).
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