Emmanuelle Bille

Emmanuelle Bille is leader of the thematic Filamentous Phage in the Neisseria team.
EB is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital.
Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on Neisseriameningitidis virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDAΦ for Meningococcal Disease Associated, associated with invasive diseases caused by N. meningitidis. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDAΦ seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.

We are member of the Bacteriophage Network France : https://site.phages.fr/

Last News of the Lab

Trends Microbiology – Microbe of the Month – Neisseria meningitidis

01/01/2025. Neisseria meningitidis. Emmanuelle Bille, Alexandra Schubert-Unkmeir and Mathieu Coureuil, Trends Microbiology 2025 ...
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New commers in the Lab

01/10/2024. We are delighted to welcome three new members: Lison Reboul for a thesis with Emmanuelle Bille on phage biologyRomina ...
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Expanding the genetic toolbox for Neisseria meningitidis

14/08/2024. Expanding the genetic toolbox for Neisseria meningitidis with efficient tools for unmarked gene editing, complementation, and labelingMorgane Wuckelt et al Applied ...
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Grant ANR PRC

24/07/2024. Mathieu Coureuil was granted ANR PRC for two project as coordinator with Sandine Bourdoulous, Anne Sophie Armand and Jean ...
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Team Members

Last Publications

  1. Bernheim, S, Chikhi, S, Foufa, I, Parize, P, Bille, E, Pontailler, M et al.. Postoperative Mediastinitis in Pediatric Cardiac Surgery: Clinical Characteristics, Management and Risk Factors for Mortality. Pediatr Infect Dis J. 2025; :. doi: 10.1097/INF.0000000000004882. PubMed PMID:40472255 .
  2. Chebib, E, Ok, V, Cohen, JF, Léger, M, Lecuyer, H, Bille, E et al.. Changes in Clinical and Microbiological Characteristics of Acute Mastoiditis in Children: A Comparative Study between 2001-2008 and 2021-2024. J Pediatr. 2025; :114672. doi: 10.1016/j.jpeds.2025.114672. PubMed PMID:40447134 .
  3. Bille, E, Schubert-Unkmeir, A, Coureuil, M. Neisseria meningitidis. Trends Microbiol. 2025;33 (3):370-371. doi: 10.1016/j.tim.2025.01.001. PubMed PMID:39863510 .
  4. Marsaux, A, Léger, PL, Rambaud, J, Bille, E, Renolleau, S, Tréluyer, JM et al.. Beta-Lactam Antibiotic Exposure During Pediatric Extracorporeal Membrane Oxygenation: Retrospective Cohort Analysis of Drug Levels Using Standard Dosing, 2018-2020. Pediatr Crit Care Med. 2024;25 (12):1127-1137. doi: 10.1097/PCC.0000000000003605. PubMed PMID:39630067 .
  5. Heid-Picard, B, Mougari, F, Pouvaret, A, Lanternier, F, Awad, Z, Bille, E et al.. Extrapulmonary Mycobacterium abscessus Infections, France, 2012-20201. Emerg Infect Dis. 2024;30 (11):2294-302. doi: 10.3201/eid3011.240459. PubMed PMID:39447147 PubMed Central PMC11521186.
  6. Rivaud, C, Oualha, M, Salvador, E, Bille, E, Callot, D, Béranger, A et al.. Improving cefazolin exposure in critically ill children using a population pharmacokinetic model. Br J Clin Pharmacol. 2025;91 (4):981-988. doi: 10.1111/bcp.16224. PubMed PMID:39209527 .
  7. Wuckelt, M, Laurent, A, Mouville, C, Meyer, J, Jamet, A, Lecuyer, H et al.. Expanding the genetic toolbox for Neisseria meningitidis with efficient tools for unmarked gene editing, complementation, and labeling. Appl Environ Microbiol. 2024;90 (9):e0088024. doi: 10.1128/aem.00880-24. PubMed PMID:39140741 PubMed Central PMC11409642.
  8. Bes-Berlandier, H, Garzaro, M, Rouzaud, C, Bodard, S, Bille, E, Ficheux, M et al.. Successful rescue TNF-α blocking for Mycobacterium genavense - Related immune reconstitution inflammatory syndrome: A case report. Heliyon. 2024;10 (7):e29341. doi: 10.1016/j.heliyon.2024.e29341. PubMed PMID:38623247 PubMed Central PMC11016716.
  9. Faury, H, Stanzelova, A, Ferroni, A, Belhous, K, Morand, P, Toubiana, J et al.. Mycobacterium canettii Tuberculosis Lymphadenopathy in a 3-Year-old Child. Pediatr Infect Dis J. 2023;42 (9):e345-e347. doi: 10.1097/INF.0000000000003983. PubMed PMID:37235762 .
  10. Tinévez, C, Lehours, P, Ranc, AG, Belaroussi, Y, Velardo, F, Dubois, D et al.. Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Campylobacter spp., France. Emerg Infect Dis. 2023;29 (3):484-492. doi: 10.3201/eid2903.221417. PubMed PMID:36823023 PubMed Central PMC9973684.
  11. Jousset, AB, Bernabeu, S, Emeraud, C, Bonnin, RA, Lomont, A, Zahar, JR et al.. Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales. J Glob Antimicrob Resist. 2023;32 :78-84. doi: 10.1016/j.jgar.2023.01.003. PubMed PMID:36708769 .
  12. Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L et al.. Correction to: Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):975-976. doi: 10.1007/s00431-022-04762-8. PubMed PMID:36529772 .
  13. Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L et al.. Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):965-973. doi: 10.1007/s00431-022-04716-0. PubMed PMID:36422708 .
  14. Thy, M, Urien, S, Foissac, F, Bouazza, N, Gana, I, Bille, E et al.. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2022;66 (12):e0113522. doi: 10.1128/aac.01135-22. PubMed PMID:36342152 PubMed Central PMC9764994.
  15. Thy, M, Urien, S, Bouazza, N, Foissac, F, Gana, I, Bille, E et al.. Meropenem Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Clin Pharmacokinet. 2022;61 (11):1609-1621. doi: 10.1007/s40262-022-01179-2. PubMed PMID:36251162 .
  16. Pizzato, J, Tang, W, Bernabeu, S, Bonnin, RA, Bille, E, Farfour, E et al.. Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI-TOF mass spectrometry paired with machine learning. Microbiologyopen. 2022;11 (4):e1313. doi: 10.1002/mbo3.1313. PubMed PMID:36004556 PubMed Central PMC9405496.
  17. de Cacqueray, N, Hirt, D, Zheng, Y, Bille, E, Leger, PL, Rambaud, J et al.. Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function. Clin Microbiol Infect. 2022;28 (10):1389.e1-1389.e7. doi: 10.1016/j.cmi.2022.05.007. PubMed PMID:35605841 .
  18. Farfour, E, Dortet, L, Guillard, T, Chatelain, N, Poisson, A, Mizrahi, A et al.. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France. Pathogens. 2022;11 (3):. doi: 10.3390/pathogens11030356. PubMed PMID:35335681 PubMed Central PMC8949168.
  19. de Cacqueray, N, Boujaafar, S, Bille, E, Moulin, F, Gana, I, Benaboud, S et al.. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. Ther Drug Monit. 2022;44 (2):319-327. doi: 10.1097/FTD.0000000000000918. PubMed PMID:35292609 .
  20. Beauruelle, C, Plouzeau, C, Grillon, A, Isnard, C, Corvec, S, Degand, N et al.. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study). Eur J Clin Microbiol Infect Dis. 2022;41 (4):581-588. doi: 10.1007/s10096-022-04402-x. PubMed PMID:35064380 .
  21. Lombes, A, Bonnin, RA, Laurent, F, Guet-Revillet, H, Bille, E, Cattoir, V et al.. High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France. Antimicrob Agents Chemother. 2022;66 (2):e0198321. doi: 10.1128/AAC.01983-21. PubMed PMID:34930033 PubMed Central PMC8846483.
  22. Tinévez, C, Velardo, F, Ranc, AG, Dubois, D, Pailhoriès, H, Codde, C et al.. Retrospective Multicentric Study on Campylobacter spp. Bacteremia in France: The Campylobacteremia Study. Clin Infect Dis. 2022;75 (4):702-709. doi: 10.1093/cid/ciab983. PubMed PMID:34849656 .
  23. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  24. Runyo, F, Beaudoin, MC, Hammadi, B, Morgand, M, Driessen, M, Sellier, Y et al.. Procalcitonin use for the screening of bacterial infections in pregnant women in the emergency ward: A prospective study. J Infect. 2021;83 (3):e4-e5. doi: 10.1016/j.jinf.2021.07.005. PubMed PMID:34271061 .
  25. Medjebeur Hanna, R, Levy, M, Bille, E, Hennequin, C, Lesage, F, Naudin, J et al.. Assessment of the Effects of a High Amikacin Dose on Plasma Peak Concentration in Critically Ill Children. Paediatr Drugs. 2021;23 (4):395-401. doi: 10.1007/s40272-021-00456-0. PubMed PMID:34142330 .
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